Several studies have shown that SLE patients have a higher prevalence of traditional risk factors, such as obesity, hypertension, and dyslipidemia, compared with the general population; also, the presence of inflammatory molecules related to SLE, such as C-reactive protein (CRP), inflammatory cytokines, and SLE pharmacotherapy, could contribute to CVD development in SLE [20,21]. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.