TNF and breast cancer: Moreover, exercise, and specifically aerobic and resistance exercise, is shown to have positive influence on cardiopulmonary function and several biomarkers (i.e., insulin, leptin, Tumour Necrosis Factor alpha (TNF-α) or sex hormone binding globulin), bone loss, body composition, depression and anxiety, and quality of life (QoL), among other factors, during BC treatment [3,4,5].