In the prevention and treatment of cancer, the influence of manganese compounds was investigated [192,193,194,195,196] in the work of Lv et al. Mn(II) was found to be essential in the detection of the innate immunity of cancerous tumours because Mn-deficient mice had significantly increased tumour growth and metastasis, with a greatly reduced number of tumour-infiltrating CD8 + T cells [194]. Here, CD8A is linked to cancer.