Subjects reporting any allergy underwent skin-prick tests and the determination of total IgE and sIgE in serum against 20 allergens, including inhaled (Graminacee, Parietaria officinalis, Dermatophagoides, and Alternaria) and food (milk, eggs, fish, shellfish, nuts/peanuts, tomatoes, citrus fruits, and soya) allergens. The gene discussed is IGHE; the disease is allergic disease.