Obesity-induced inflammation, caused by excessive dietary intake, plays an important role in CRC risk and progression, notably through the continuous increased secretion of pro-inflammatory cytokines in the circulation and tissues, such as interleukin (IL)-1, IL-6, IL-8, and tumour necrosis factor-α (TNF-α) [5]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.