Leptin levels are elevated in obese subjects, which stimulates cell growth, proliferation, migration, and invasion by activating the leptin receptor and transcription 3 (STAT3) pathway, which modulates extracellular signal-regulated kinase (ERK) signalling to increase inflammatory cytokines, promote tumour vascularization, and inhibit apoptosis [4]. The gene discussed is LEP; the disease is neoplasm.