However, allergic disease cannot be determined by the test itself but rather by the physician who takes into consideration the patient’s clinical history of type 1 hypersensitivity-associated reactions following a relevant allergen exposure and other patient and environmental risk factors (e.g., IgE antibody levels, total serum IgE levels, the patient’s family genetic history, the severity of the reported reactions, type of reactions, possible cross-reactive allergen exposure). The gene discussed is IGHE; the disease is allergic disease.