Enzyme inhibition reduced the risk of NCD occurrence including Alzheimer’s disease (β-secretase (BACE-1), butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)), obesity (lipase), hypertension (angiotensin-converting enzyme (ACE)) and diabetes mellitus (dipeptidyl peptidase-IV (DPP-IV), α-glucosidase and α-amylase). The gene discussed is BACE1; the disease is obesity due to melanocortin 4 receptor deficiency.