Our study indicates that Nar can promote autophagy and reduce excessive fat accumulation by regulating hlh-30, lgg-1, unc-51, pha-4, skn-1, yap-1, and other genes associated with lipid levels, providing a theoretical basis for the prevention of diabetes and obesity. The gene discussed is CPSF4; the disease is obesity due to melanocortin 4 receptor deficiency.