This was supported by another SRMA of RCTs published in 2020, assessing the effect of pistachio intake on glycemic control in individuals with different health statuses (type 2 diabetes, prediabetes, and metabolic syndrome), which showed a significant reduction in fasting glucose and HOMA-IR but not HbA1c or fasting insulin [34]. The gene discussed is INS; the disease is prediabetes syndrome.