↓ Bile acids, lysine, arachidonic acid and sphingolipids; ↑ xanthine and hypoxanthine vs. negative control↑ FXR IHC score vs. carrier and negative control↑ FXR expression in eTRF vs. negative control↓ NAFLD activity score vs. negative control. The gene discussed is NR1H4; the disease is metabolic dysfunction-associated steatotic liver disease.