KRT18 and metabolic dysfunction-associated steatotic liver disease: In a 48-week study comparing αTF with annatto T3 supplementation in NAFLD, both treatments improved fatty liver index and glycaemic status, as well as inflammatory and oxidative stress markers [44], but annatto T3 was significantly more effective at decreasing body weight, circulating inflammatory cytokines and cytokeratin-18 fragment M30 (a hepatocyte apoptosis marker) than αTF [44].