Several natural polyphenols have been reported to exert anti-obesity effects by inhibiting adipocyte differentiation through the suppression of C/EBPα, PPAR-γ, FAS, SREBP-1C, and lipid metabolism (ACC-1, AMPK, FAS, and PPAR-α) [41]. This evidence concerns the gene PPARA and obesity due to melanocortin 4 receptor deficiency.