Data were extracted for 468,787 genes, and pancreatic islet CpG sites from 89 donors showed that SNPs influence gene methylation (adenylate cyclase 2 (ADCY2), potassium inwardly rectifying channel subfamily J member 11 (KCNJ11), traits of glucose-like growth factor receptor bound protein 10 (GRB10), and PDX1), all of which are responsible for epigenetic deregulation in pancreatic islets of T2D patients [45]. The gene discussed is ADCY2; the disease is type 2 diabetes mellitus.