Jiang et al. [42] found that Tan IIA significantly attenuated the accumulation of FN and collagen in the renal tubular interstitium of a mouse model of folic acid-induced AKI and also inhibited the recruitment of CD45+ and type I collagen (COL-I)-positive fibroblasts to the kidney; further studies revealed the expression of chemokines of fibroblasts in the kidney, such as TGFβ1 and MCP-1, and significantly reduced the early stage of renal injury. This evidence concerns the gene TGFB1 and acute kidney injury.