Although Charcot–Leyden crystal proteins are not a major determinant of human regulatory T-cell function (viability) [41], CLC is one of luminal-captured biomarkers of inflammation and eosinophilic esophagitis [42], and Gal-10 expression in the nasal polyps of patients with chronic rhinosinusitis was correlated with the severity of the disease according to Clinical-Cytological Grading [43]. This evidence concerns the gene CLC and chronic rhinosinusitis.