Moreover, high levels of CLCs, chemokine (C-C motif) ligand 17, cystatin SN, interleukin (IL)-5, and macrophage inflammatory protein-1β in nasal secretions have been found to be associated with poor prognosis in chronic rhinosinusitis patients under surgical and conventional medical treatments [47]. The gene discussed is ABCB1; the disease is chronic rhinosinusitis.