However, our studies of the ELE treatment group on physical parameters white adipose tissue (WAT weight) and plasma parameters (adiponectin) as well as gene expression analysis by real-time PCR in adipose tissue clearly indicated the high anti-obesity effect by the energy expenditure in the adipose tissue (Table 3 and Table 4). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.