CYFIP1 and fragile X syndrome: In another study by Santini et al., treatment of FXS mice with 4EGI-1 reversed the defects in cognition and spine morphology as well as normalized the phenotypes of enhanced metabotropic glutamate receptor (mGluR)-mediated LTD and dysregulated CYFIP1/eIF4E interactions in FXS mice, which further highlights the pathogenic role of exaggerated cap-dependent mRNA translation in ASD.