The results showed that permethrin had a stronger cytotoxic effect on the liver tumor cell line Hep-G2, and a higher cytotoxic effect on a non-hepatic tumor cell line (HeLa) also with a high furin expression, while the killing of normal liver cells L-02 with low furin expression was much weaker than that of Hep-G2 cancer cells from the same tissue. The gene discussed is FURIN; the disease is cancer.