Obesity induces upregulated expression of chemokines such as MCP-1 (monocyte chemoattractant protein-1, CCL2) and CCL5 (C-C Motif Chemokine Ligand 5) in order to recruit M1 macrophages to adipose tissues [39]. This evidence concerns the gene CCL5 and obesity due to melanocortin 4 receptor deficiency.