NOS2 and diabetes mellitus: Proanthocyanidins in tea, black currant, grapes, bilberry, pine bark, cranberry, and peanut skin may lead to a decrease in the oxidative stress (ROS), induce lower iNOS and COX-2 over-expression, then lower inflammation, and, lastly, show activities against diabetes, asthma, neuropathologies, cardiovascular ailments, obesity, and cancer [466].