Compared with the previous study, this study further understood the structural information of PPZM by using saccharide mapping, the neuroprotective effects of PPZM were further confirmed by an Aβ25–35-induced damage model in PC12 cells, and the potential neuroprotective mechanisms of PPZM on AD were further explored through the Nrf2/HO-1 signaling pathway. This evidence concerns the gene HMOX1 and Alzheimer disease.