Therefore, we evaluated the effects of the C. europaea extracts on human leukemia and hepatocellular carcinoma cell lines, pain, burns, and the potential effect of the natural components identified in C. europaea polyphenols, to inhibit CK1 and GSK3B implicated in the Wnt/β-catenin signaling pathway, tyrosine kinase associated to leukemic cancer, and cox-2 implicated in the analgesic effect. The gene discussed is GSK3B; the disease is hepatocellular carcinoma.