NFE2L2 and glaucoma: In 2019, another ingredient of coffee, CGA, was demonstrated to promote lncRNA-TUG1 expression, which positively regulated nuclear factor erythroid-2 related factor 2 (Nrf2) expression, and thus, decreased H2O2-induced retinal ganglion cell (RGC) apoptosis and ROS level, as well as increased RGCs viability in vitro, suggesting that CGA could prevent oxidative stress injury and protect against glaucoma [46].