ERK exists widely in tissues and participates in the regulation of cell proliferation and differentiation; JNK is a vital signal molecule in cellular signal transduction; and p38 MAPK consists of five members (p38α, p38β1, p38β2, p38γ, and p38δ) that mediate apoptosis and inflammation [41], and can either inhibit tumor cell homeostasis, proliferation, differentiation, and apoptosis, or enhance tumor development and metastasis. Here, MAPK8 is linked to neoplasm.