Therefore, we performed this study to investigate the anti-obesity and anti-steatotic effects of chrysin in an HFD-rat model of obesity and to explore the possible mechanism(s) of these actions through the study of the changes in the pathogenic pathways involved in the hepatic manifestations of obesity, including glucose and lipid homeostasis, AMPK/mTOR/lipogenesis pathways, adipokines, redox status, inflammation, and mitochondrial biogenesis. The gene discussed is MTOR; the disease is obesity due to melanocortin 4 receptor deficiency.