In accordance with our results, caspase 3 was recently shown to be weakly expressed in intact hepatocellular carcinoma HepG2 cells [67], supporting earlier findings documenting the lower expression of caspase 1 and caspase 3 in hepatocellular carcinoma tissue compared to nontumor cells [68,69]. This evidence concerns the gene CASP1 and hepatocellular carcinoma.