APEX1 and lung cancer: Isoginkgetin 9 at from 2.5 to 20 μmol/L was reported to have an apparent inhibitory effect on A549 lung cancer cells via upregulating the expression of miR-27a-5p and downregulating the level of apurinic/apyrimidinic endo-deoxyribonuclease 1 (APEX1) [34], and sotetsuflavone 11 at 200 mmol/L showed the same inhibition of A549 cells but with relation to increased E-cadherin and decreased N-cadherin [37].