TG2 is noteworthy due to its transamidase activity involved in liver fibrosis, its deamidation role in celiac disease, and its intracellular G-protein activity [9,10,11] which has been implicated in numerous cancer models including the epithelial-mesenchymal transition of cancer stem cells [12,13,14,15,16,17]. This evidence concerns the gene TGM2 and cancer.