HMOX1 and liver cancer: In our study, the expression level of HMOX1 gene was significantly raised in all three curcumin-treated liver cancer cell lines (Table S1), and HMOX1 was enriched in these biological processes, such as cellular iron ion homeostasis, cellular transition metal ion homeostasis, cellular response to metal ion, iron ion homeostasis, response to iron ion, response to metal ion and transition metal ion homeostasis (Figure 1F), indicating the possibility that curcumin regulated ferroptosis via HMOX1.