An investigation performed on an apolipoprotein E–deficient (apo E–/–) mice model of atherosclerosis showed that a dietary supplement composed of bilberry anthocyanin-rich extract, including over 50% of pure anthocyanins ingested for two weeks, was able to lower plasmatic total cholesterol (about 20%) and hepatic triglyceride levels (about 30% in the liver). This evidence concerns the gene APOE and atherosclerosis.