A previous study showed significant correlations between total IgE serum levels with the Sino-Nasal Outcome Test scores, Lund–Mackay computed tomography scan scores, and polyposis recurrence in 50 adult CRS patients with nasal polyposis, along with interleukin-17 and pentraxin-3 levels [43]. The gene discussed is PTX3; the disease is congenital rubella syndrome.