SNORD94 and systemic sclerosis: An important body of evidence supports the role of HCMV and HHV-6 in SSc etiopathogenesis: both viruses have been found reactivated in the skin of SSc subjects (the HHV-6A species, in particular, has the more marked tissue tropism) [10,19], who also were characterized by a strong activation of antiviral humoral immunity, showing significantly higher amounts of antibodies directed toward viral antigens, such as UL94 (HCMV) and U94 (HHV-6), compared to healthy controls [10,20,21,22,23].