In the absence of IL−10, S100G expression was elevated, inflammatory changes were reduced after the induction of colitis, and S100G inhibited monocyte chemoattractant protein−1 (MCP−1) production by inhibiting NF−κB activation, which is an important anti−inflammatory mediator in fibroblasts after the induction of colitis [24]. Here, NFKB1 is linked to colitis.