Activation of the vitamin D receptor could play a modulatory role to the host response in the acute respiratory distress syndrome by decreasing cytokines, producing a shift toward amplified adaptive Th2 immune responses, regulating the renin-angiotensin-bradykinin system, modulating neutrophil activity, and maintaining the integrity of the pulmonary epithelial barrier, thus promoting epithelial repair, and decreasing the coagulability and prothrombotic tendency associated with SARS-CoV-2 infection [30,31,32]. This evidence concerns the gene REN and acute respiratory distress syndrome.