IL6 and cancer: Analyzing new therapeutic targets, IL-6 is certainly associated with liver tumorigenesis in early stages; recent studies investigated the synergistic effect of IL-6 inhibition in combination with inhibitors of PI3K/Akt/mTOR signaling cascade and immunotherapy in cancer treatment, finding stronger effects on HCC progression of the combination IL-6 antibody and NVP-BEZ235 treatment [167].