Cytokines and chemokines significantly increased in NAFLD-related HCC are IL-8, IL-13, C-C motif chemokine ligand 3 (CCL3), CCL4 and CCL5, which are involved in fibrosis progression and hepatocarcinogenesis and, interestingly, are produced by an LPS-dependent mechanism [93,94,95,96]. The gene discussed is CCL3; the disease is hepatocellular carcinoma.