miR-146a-5p reduces the production of IL-1β, IL-6 and TNF-α after HSC incubation with LPS [171] and can decrease the production of a-smooth muscle actin (ASMA) [172], which is synthesized by HSCs upon LPS induction [173] and is associated with an immunosuppressive microenvironment and poor HCC prognosis [174,175]. Here, IL6 is linked to hepatocellular carcinoma.