Although it is still premature to claim that the observed reduction in MAPK8IP1 in diabetic islets is involved in the pathophysiology of diabetes, the negative correlation of MAPK8IP1 expression with HbA1c levels and positive correlation with β-cell functional genes indicates the important role of MAPK8IP1 in the physiology of β-cell. Here, MAPK8IP1 is linked to diabetes mellitus.