Exploration of the effect of diabetes/hyperglycemia status on the mRNA expression of MAPK8IP1 showed a significant reduction in the case of diabetic/hyperglycemic islets (HbA1C ≥ 6%; n = 21) compared to nondiabetic/normoglycemic islets (HbA1c < 6%; n = 50) (p = 0.04) (Figure 1B). Here, MAPK8IP1 is linked to Hyperglycemia.