GCKR and metabolic dysfunction-associated steatotic liver disease: We found 28 novel significant associations of the GCKR variant with metabolites (mainly glycerolipids, glycerophospholipids, and amino acids) in men with NAFLD, and replicated previously reported associations with pyruvate, lactate, threonine, 3-aminoisobutyrate, glycerolipids, and glycerophospholipids [46].