Figure 1 shows the groups of metabolites associated with NAFLD. The PNPLA3 variant was associated with several metabolite groups, whereas the TM6SF2 and GCKR variants were mainly associated with glycerolipids and glycerophospholipids and the PPP1R3B variant with steroids, amino acids, and glycerophospholipids. The gene discussed is GCKR; the disease is metabolic dysfunction-associated steatotic liver disease.