Although many results were described, further mechanistic research revealed that wogonin inhibited colorectal tumor development by regulating Nrf2 activation and signaling and decreasing the nuclear translocation of NF-κB and phosphorylation of IkB and IKKα/β in HCT116 cells and THP-1 cells. The gene discussed is NFE2L2; the disease is colorectal neoplasm.