Quercetin could exert antitumor effects by preventing hepatocellular carcinoma LM3 cells from proliferating, migrating and invading, causing cell cycle arrest and apoptosis and stimulating HCC autophagy via abrogating the JAK2/STAT3 signaling pathway (by downregulating JAK2 and STAT3) [15]. The gene discussed is JAK2; the disease is hepatocellular carcinoma.