It has been observed that the FADS genes are associated with the differences in adipose tissue, body weight, and glucose homeostasis and these are regulated by PUFAs [78], which is consistent with our results that FADS1-3 have strong correlations with obesity and T2D traits in adipose, liver, and muscle tissues in ApoE−/− C57BL/6J and C3H/HeJ mice (Supplementary Figure S3). This evidence concerns the gene APOE and obesity due to melanocortin 4 receptor deficiency.