As shown in Table 3, Rodriguez-Cruz and Morris reported that MCT1 inhibitors (AR-C155858, AZD-3965) significantly reduced respiratory depression and sedative effects caused by the co-administration of GHB and ethanol and decreased the brain concentration and brain-to-plasma concentration ratio of GHB at return of righting reflex (RRR) [19]. This evidence concerns the gene SLC16A1 and respiratory depression.