Pregnancy toxemia in ewes inhibits expression of the ACM-related genes 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA), 3-hydroxy-3-methylglutaryl coenzyme A synthase 1 and 2 (HMGCS1 and HMGCS2), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) [20]. The gene discussed is HMGCR; the disease is toxemia of pregnancy.