The overexpression of the TMEM16A is associated with many types of cancer, including gastrointestinal stromal tumors, gastric cancer, head and neck squamous cell carcinoma, colon cancer, pancreatic ductal adenocarcinoma, lung tumours and esophageal cancer [9,13,14,15,16,17]. The gene discussed is ANO1; the disease is gastrointestinal stromal tumor.