After mutation signature analysis, no differential mutated genes with p < 0.05 were found in the GBM cohort, while EGFR and NF1 mutated more frequently in the high-risk group, and IDH1, CIC, NOTCH1, and FUBP1 were identified mutated more frequently in the low-risk group in LGG cohort (Figure 7B). The gene discussed is EGFR; the disease is glioblastoma.