Moreover, PlGF has been shown to play a role in development and the function of the placental vascular network, and there has been evidence that the placentas of women with GDM and pre-existing type 1 and 2 diabetes mellitus are characterized by a higher total area of the terminal villi of the placenta and an increased number of small vessels [67,68,69]. The gene discussed is PGF; the disease is gestational diabetes.