Additionally, it has been reported that testosterone and sex-hormone binding globulin levels are lower in men with obesity and inversely correlate with the degree of obesity [28,29].This condition triggers a vicious cycle in which low testosterone contributes to maintaining a high body weight and accumulation of intra-abdominal fat, leading to a greater degree of testosterone deficiency [30]. The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.