DSG2 and Arrhythmia: Since the patient later developed bradycardia, a gene panel for cardiac arrhythmias (Invitae Arrhythmia and Cardiomyopathy Comprehensive Panel, including 168 genes) was recommended, which revealed the presence of a heterozygous mutation of the DSG2 gene (c.308T>C) (p.Val103Ala), a variant of unknown significance (VUS) [12].