MKI67 and neoplasm: It is not the aim of this review to discuss staging and prognostic factors of PanNETs, but exclusion of liver, lung, or lymph nodes metastases as well a careful evaluation of tumor grading, the Ki-67 proliferation index, and other prognostic factors, which are of paramount importance to indicate or rule out EUS-RFA [55,56,57,58,59,60,61,62,63,64].