HK2 and carcinoma of esophagus: In the last two decades, studies have revealed that the overexpression of HK2 has existed in many types of cancer, such as cervical cancer [43], esophageal carcinoma [44], etc. Many studies have argued that ROCK1 (Rho-associated coiled-coil containing protein kinase 1) is engaged in cell proliferation, motility, and metastasis, and so ROCK1 may be a promising therapeutic target for carcinoma therapy [45,46].