By analyzing the ratio of 22 types of immune cells in two risk groups, we found that the infiltration levels of resting memory CD4 T cells, M0 macrophages, M2 macrophages, and activated mast cells were significantly upregulated in the high-risk group, with an adverse OS rate, showing the critical work of these cells in the initiation and progression of CESC. This evidence concerns the gene CD4 and cervical squamous cell carcinoma.