Patients with liver disease are often more likely to experience thrombosis as a result of increased platelet aggregation caused by high von Willebrand (vWF) factor activity and low rates of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif 13), a variable of von Willebrand factor action [35]. The gene discussed is VWF; the disease is liver disorder.