In the ENGAGE AF-TIMI 48 trial, when ALT or AST > 2x UL or total bilirubin > 1.5 UL, anemia (hemoglobin under 10 g/dL), or thrombocytopenia (100.000/m3), precaution is recommended for edoxaban [27]. The gene discussed is GPT; the disease is anemia (phenotype).