Pinhas-Hamiel [3] hypothesized that food preoccupation imposed by carbohydrate counting, weight fluctuations associated with variable use of insulin, and the subsequent body and blood glucose fluctuations associated with mismatched insulin dose, as well as excessive caloric intake secondary to hypoglycemia, can burden those with T1D and may increase their vulnerability to the development of DEBs. This evidence concerns the gene INS and Hypoglycemia.